unsaturated vegetable fats
Jul. 25th, 2017 12:48 pm![[personal profile]](https://www.dreamwidth.org/img/silk/identity/user.png){kind=small}
leo_sosnineВ лит-ре стращают трансфатами и советуют polyunsaturated fats, ну, типа, оливковое масло и т.п. Помогает против сердечных проблем, типа. Как вдруг читаю:
Abstract
In an eight-year controlled clinical trial of a diet high in polyunsaturated vegetable oils and low in saturated fat and cholesterol in preventing complications of atherosclerosis, 846 men were assigned randomly to a conventional diet or to one similar in all respects except for a substitution of vegetable oils for saturated fat. Fatal atherosclerotic events were more common in the control group (70 v.48; P<0·05). However, total mortality was similar in the two groups: 178 controls v. 174 experimentals, demonstrating an excess of non-atherosclerotic deaths in the experimental group. This was accounted for by a greater incidence of fatal carcinomas in the experimental group. 31 of 174 deaths in the experimental group were due to cancer, as opposed to 17 of 178 deaths in the control group (P=0·06).
http://www.sciencedirect.com/science/article/pii/S0140673671910865
Что делать? Куды бечь? Не от сердца, так от канцера, лол. Мб рыбий жир жрать заместо этого всего
Abstract
In an eight-year controlled clinical trial of a diet high in polyunsaturated vegetable oils and low in saturated fat and cholesterol in preventing complications of atherosclerosis, 846 men were assigned randomly to a conventional diet or to one similar in all respects except for a substitution of vegetable oils for saturated fat. Fatal atherosclerotic events were more common in the control group (70 v.48; P<0·05). However, total mortality was similar in the two groups: 178 controls v. 174 experimentals, demonstrating an excess of non-atherosclerotic deaths in the experimental group. This was accounted for by a greater incidence of fatal carcinomas in the experimental group. 31 of 174 deaths in the experimental group were due to cancer, as opposed to 17 of 178 deaths in the control group (P=0·06).
http://www.sciencedirect.com/science/article/pii/S0140673671910865
Что делать? Куды бечь? Не от сердца, так от канцера, лол. Мб рыбий жир жрать заместо этого всего
Потирая руки
Date: 2017-07-30 01:18 pm (UTC)> Следовали все
Смотрим таблицу VI - Adherence to diet in the total study population и видим там, что у большинства участников эксперимента этот самый adherence далеко не 100%.
> Про p-value херню написали
Опять смотрим в статью и видим следующее: "In 1969 we presented the results of an eight-year clinical trial designed to determine whether a diet which lowers serum-cholesterol levels can also reduce clinical manifestations of atherosclerosis. Fatal acute atherosclerotic events were significantly more common in the controls than in the experimental group. Despite this difference, total mortality was scarcely affected" (выделение моё).
То есть целью эксперимента было померять влияние диеты на атеросклероз. Результат оказался отрицательным. После этого неугомонные учёные начали искать в тех же данных что-нибудь другое статистически значимое. И нашли - ура! - влияние диеты на рак. Прямо по XKCD 882.
Re: Потирая руки
Date: 2017-07-30 01:38 pm (UTC)